四虎成年永久免费网站-四虎成人4hutv影院-四虎成人www国产精品-四虎成人国产精品视频-四虎成人精品-四虎成人精品国产一区a

您好,歡迎進入上海力敏實業有限公司網站!
一鍵分享網站到:
您現在的位置:首頁 >> 產品中心 >> 生化試劑、抗體、血清 >> 細胞因子 >> RD 3339-FB-025R&D供應商Recombinant Rat FGF basic 重組大鼠堿性成纖維細胞生長因子

R&D供應商Recombinant Rat FGF basic 重組大鼠堿性成纖維細胞生長因子

  • 更新時間:  2023-07-25
  • 產品型號:  RD 3339-FB-025
  • 簡單描述
  • Recombinant Rat FGF basic ,Recombinant Human FGF basic ,Recombinant Human KGF/FGF-7,Recombinant Human/Mouse FGF-8b
詳細介紹

DESCRIPTION
Source E. coliderived
Ala11Ser154
Accession # P13109
Nterminal
Sequence
Analysis
Ala11
Predicted Molecular
Mass
16.2 kDa
SPECIFICATIONS
Activity Measured in a cell proliferation assay using NR6R-3T3 mouse fibroblast cells. Rizzino, A. et al. (1988) Cancer Res. 48:4266? Thomas, K. et
al. (1987) Methods Enzymol. 147:120.
The ED50 for this effect is typically 0.31.8
ng/mL.
Endotoxin Level <1.0 EU per 1 μg of the protein by the LAL method.
Purity >95%, by SDSPAGE
under reducing conditions and visualized by silver stain.
Formulation Lyophilized from a 0.2 μm filtered solution in MOPS, Na2SO4, EDTA and DTT with BSA as a carrier protein. See Certificate of Analysis for
details.
PREPARATION AND STORAGE
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediay at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freezethaw
cycles.
l 12 months from date of receipt, 20
to 70
°C as supplied.
l 1 month, 2 to 8 °C under sterile conditions after reconstitution.
l 3 months, 20
to 70
°C under sterile conditions after reconstitution.
BACKGROUND
FGF basic (FGF2,
HBGF2)
is one of at least 22 mitogenic proteins of the FGF family, which show 35 60%
amino acid conservation (1 3).
Unlike other FGFs,
FGF acidic and basic lack signal peptides and are secreted by an alternate pathway. Storage pools within the cell or on cell surface heparan sulfate proteoglycans
(HSPG) are likely. The predicted 18 kDa FGF basic isoform can be located in both the cytoplasm and the nucleus and is presumed to be the form secreted (4).
Transcription from alternate start sites produces 21 23
kDa forms found only in the nucleus. High and low molecular weight human FGF basic targets the expression
of different genes when expressed in NIH3T3
cells (5). The 18 kDa rat sequence has 98% amino acid (aa) identity with mouse, and 96 97%
aa identity with human,
bovine and sheep FGF basic (6, 7). Autocrine, intracrine and paracrine actions of FGF basic have been identified. Binding of FGF to heparin or cell surface HSPG is
necessary for binding, dimerization and activation of tyrosine kinase FGF receptors. FGF basic binds other proteins, polysaccharides and lipids with lower affinity (3).
Expression of FGF basic is nearly ubiquitous but disruption of the mouse FGF basic gene gives a relatively mild phenotype, suggesting compensation by other FGF
family members. FGF basic modulates such normal processes as angiogenesis, wound healing and tissue repair, embryonic development and differentiation, neuronal
function and neural degeneration. Transgenic overexpression of FGF basic results in excessive proliferation and angiogenesis reminiscent of a variety of pathological
conditions (1 3).
References:
1. Coulier, F. et al. (1997) J. Mol. Evol. 44:43.
2. Fernig, D. et al. (1994) Prog. Growth Factor Res. 5:353.
3. Presta, M. et al. (2005) Cytokine Growth Factor Rev. 16:159.
4. Claus, P. et al. (2003) J. Biol. Chem. 278:479.
5. Quarto, N. et al. (2005) Gene 356:49.
6. Tsuneto, M. et al. (2005) Biochem. Biophys. Res. Commun. 335:1239.
7. Shimasaki, S. et al. (1988) Biochem. Biophys. Res. Commun. 157:256.
Recombinant Rat FGF basic
Catalog Number: 3339-FB
 

 

上海力敏實業有限公司代理R&D產品,咨詢 
上海力敏實業有限公司代理R&D產品,咨詢 


留言框

  • 產品:

  • 您的單位:

  • 您的姓名:

  • 聯系電話:

  • 常用郵箱:

  • 省份:

  • 詳細地址:

  • 補充說明:

  • 驗證碼:

    請輸入計算結果(填寫阿拉伯數字),如:三加四=7
主站蜘蛛池模板: 色综合91| 37pao成人国产永久免费视频 | 日本日本在线观看视频 | 884aa草莓视频 | 九九精品热线免费观看6 | 爱搞逼综合网 | 色多网站免费视频 | 成人久久18免费网站入口 | 久久久久久久久影院 | 日本免费观看完整视频 | 欧美在线日韩在线 | 欧美人人干 | 国产精品高清久久久久久久 | 99久久2019re6热精品首页 | 波霸影院一区二区 | 亚洲最大色网 | 欧美精品中文 | 在线播放五十路乱中文 | 日韩免费观看一级毛片看看 | 最近在线更新中文字幕1 | 亚洲区日韩精品中文字幕 | 亚洲精品一区二区三区福利 | 日韩福利 | 欧美激情在线精品一区二区 | 日韩精品亚洲一级在线观看 | 婷婷在线视频国产综合 | 隔壁老王国产精品福利 | 手机看片高清日韩精品 | 一区二区免费视频 | 欧美波霸影院在线观看 | 精品国产日韩亚洲一区二区 | 国产精品亚洲精品久久成人 | 亚洲香蕉久久一区二区三区四区 | 精品国产日韩亚洲一区二区 | 青草视频久久 | 成人免费aa在线观看 | 国产欧美日韩在线观看精品 | a级毛片免费网站 | 中文字幕一区在线观看视频 | 国产成人经典三级在线观看 | 久久草在线视频 |